Föstudagur, August 25, 2017 -
10:00 to 11:00
Testicular steroidogenic cells in health and disease Malgorzata Kotula-Balak currently serves as an Assistant Professor (with PhD. DSc. in 2014) in the Department of Endocrinology, Institute of Zoology, Faculty of Biology and Earth Sciences at the Jagiellonian University.
Abstract Sex steroid producing cells of the testis were discovered by Franz Leydig in 1850. His perfect description of testicular steroidogenic cells was for the next decades confirmed and developed based on the results from both experimental and epidemiological studies. Recent data revealed two (three in human) Leydig cells proliferation waves. The physiology, biochemical features as well as mechanisms of individual population degradation and its fluent replacement is scarcely known. On the other hand the multi-levels regulation of steroidogenesis is explored in more details. This process is under control of gonadotropin and other hormonal (e.g. thyrotropin, estrogens) and non-hormonal (e.g. cAMP, steroidogenic acute regulatory protein) factors. Androgen production begins in fetal Leydig cells, thus development and differentiation of the gonad and its cells is controlled at very beginning. Proper Leydig cells function is reflected by the balance between androgens and estrogens produced by these cells. Any disturbance in morphology and/or steroid biosynthesis (primary or secondary hormonal imbalance) results in serious testicular dysfunctions (e.g. cryptorchidism, spermatogenesis defect and/or inhibition). The latter one is revealed in Klinfelter’s syndrome where spermatogenesis is destroyed and Leydig cells became hypertrophic and hyperplastic producing an excess of estrogens. Nowadays, cryptorchidism is one of the most frequent cause of male infertility. In this disease defect of Leydig cells and spermatogenesis disturbances can be a consequence of action of hormonally active environmental chemicals with anti-androgenic or estrogenic properties. Similarly, Leydigioma (Leydig cells tumor) can be initiated by an altered estrogen microenvironment (increased estrogen level and/or altered signalization). These and other related issues on Leydig cells physiology and pathology and its relation to testis function will be presented herein based on own and recent literature data. Schedule of the Friday biology talks http://luvs.hi.is/fyrirlestrar_haustid_2017