Líf- og umhverfisvísindastofnun

The generation of variation and the genetics of complex morphologies

Dagsetning: 
Þriðjudagur, Janúar 29, 2019 -
12:30 to 13:30
Nánari staðsetning: 
N132

Professor Benedikt Hallgrímsson at University of Calgary will present his work on the generation of variation and the genetics of complex  morphologies.

Research projects in his lab include. Descriptions of projects and biographicial sketch are from the Hallgrimson lab page at the University of Calgary.

Evolutionary developmental biology of the skull
 
Through a combination of mouse and chick based studies of both embryos and post-natal organisms, we are interested in studying the evolutionary developmental biology of the skull to discover the genetic and developmental processes that cause organisms to look different from one another. This involves studying form and the underlying developmental mechanisms that interact with each other and with functional constraints to produce a phenotype.
 
 
Bone imaging and bone disease
 
The lab uses various mice models, including mice from the Collaborative Cross, to investigate the factors that lead to diseases such as osteroarthritis and osteoporosis. This involves looking at bone microstructure in combination with bone breakage to investigate bone strength in long bones, and also investigating the relationship between bone shape and strength.
 
 
Genetics of Normal Facial Variation

One project in the lab focuses on increasing our understanding of normal facial variation. The lab is part of the Facebase Consortium and is invovled with the study of normal facial variation. We have taken multiple trips to work with collaborators in Mwanza, Tanzania to collect 3d images, DNA, and anthropometric measures from children there. The goal is quantify the extent and direction of facial variation in this sample and then to link this variation with genetic variants via a GWAS.

Benedikt Hallgrimsson visits Iceland to evaluate the Ph.D. thesis of Samantha Beck, which worked on her project at Holar University College and graduates from the University of Iceland.

Benedikt Hallgrímsson was born in Reykjavík, Iceland and completed his studies at the University of Alberta and The University of Chicago.  He is a biological anthropologist and evolutionary biologist who combines developmental genetics and bioinformatics with 3D imaging and morphometrics to address the developmental basis as well as evolutionary significance of phenotypic variation and variability. His work has focused on the mammalian craniofacial complex, craniofacial dysmorphology in humans, and skeletal biology and disease and has employed both experimental and comparative approaches. Among other accomplishments, he was awarded the Rohlf medal for excellence in Geometric Morphometrics in 2015. and is currently the chair of the Department of Cell Biology and Anatomy and the Theme Leader for the Genes, Development and Health theme of the Alberta Children's Hospital Research Institute. He is also a full member of the McCaig Institute for Bone and Join Health.

Figure from paper: Hallgrimsson B, Mio W, Marcucio RS, Spritz R (2014) Let's Face It—Complex Traits Are Just Not That Simple. PLoS Genet 10(11): e1004724. https://doi.org/10.1371/journal.pgen.1004724

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http://luvs.hi.is/vor_2019

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