Einar Árnason, University of Iceland will present a very exciting research project on a newly-developed modelling method in evolutionary biology.
In Aksja, room 131. At: 12:30
Identifying loci under positive selection in complex population histories, Graph-aware retrieval of Selective Sweeps: GRoSS
Einar Árnason, Katrín Halldórsdóttir.
University of Iceland.
Modeling a species' history of population splits or mergers is important for understanding the operation of natural selection in the different populations. Population differentiation-based methods have had some success. Examples are pairwise Fst comparisons (e.g. Lewontin-Krakauer test), a three-population branch statistic (PBS), or higher population-number comparisons. However, none of these methods use admixture graphs of explicit relationships among a set of populations. We present a method, called "Graph-aware retrieval of Selective Sweeps: GRoSS" useful for analyzing multiple populations that are related in complex ways. The method can detect selective sweeps and importantly can pinpoint in which populations or branches of the graph of relationships among populations selection most likely took place. GRoSS has been used on genomic data from humans, cattle, and Atlantic cod. We will present ad discuss some of these results.
The programme of the Friday seminars for this semester can be found here.